The ongoing climate and biodiversity crises suggest that simply protecting species or ecosystems is insufficient and broader ecosystem restoration is needed. We hypothesise that depopulation, which is reshaping socio-ecological systems in rural Europe and driving fundamental changes to ecosystems, has the potential to be a key element in the transformative change needed to safeguard biodiversity and support climate change mitigation. At the same time, it reduces the demand for ecosystem services, offering new opportunities for nature restoration.